Nurse Practitioners in the La Crosse, WI area can find excellent job opportunities in nearby cities. Winona, MN, stands out with an average salary of $307,846. Rochester, MN, follows closely with an average salary of $163,617. Madison, WI, and Eau Claire, WI, also offer competitive salaries for Nurse Practitioners, with averages of $163,546 and $136,309, respectively.