Medical Directors can expect competitive salaries in several top cities. San Diego, California, leads the way with the highest average salary at $253,221. Los Angeles, California, follows closely with an average salary of $248,653. These cities offer strong opportunities for those in medical leadership roles. In addition to California, Chicago, Illinois, and Boston, Massachusetts, provide robust salaries for Medical Directors. Chicago offers an average salary of $240,251, while Boston provides $221,959. Oklahoma City, Oklahoma, rounds out the list with an average salary of $221,275. These cities present attractive options for job seekers in the medical field.