What is the average salary in South San Francisco, CA?
South San Francisco, CA, offers a variety of job opportunities with competitive salaries. On average, professionals can expect to earn $84,276 per year. Many positions offer above-average wages, particularly in sectors like technology and biotech.
Here are some common industries with their average salaries:
- Information Technology: $133,765
- Healthcare: $94,779
- Manufacturing: $75,286
- Education: $55,793
- Retail: $36,300
What are the best paying jobs in South San Francisco, CA?

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Software Engineer
Average Salary: $168,129
Engineers create and test software. They work for companies like Genentech and Illumina. Their role involves improving software for better performance.
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Registered Nurse
Average Salary: $133,696
Nurses care for patients. They work in hospitals and clinics. Their role includes monitoring patients and administering medications.
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Technical Project Lead
Average Salary: $133,315
Project leads manage technical projects. They coordinate with teams to meet goals. They work for companies like Gilead Sciences and Regeneron.
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Scientist
Average Salary: $113,995
Scientists conduct research and experiments. They work in labs and on projects. They find new ways to improve products and processes.
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General Manager
Average Salary: $87,894
Managers oversee daily operations. They ensure the company runs smoothly. They make important decisions and manage staff.
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Sales Manager
Average Salary: $86,629
Sales managers lead sales teams. They set sales goals and train staff. They work to increase sales and improve performance.
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Operations Manager
Average Salary: $85,304
Operations managers handle business operations. They ensure efficiency and effectiveness. They work closely with staff to improve processes.
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Research Associate
Average Salary: $84,621
Associates conduct research. They collect and analyze data. Their work helps companies understand market trends and improve products.
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What are the best paying jobs in South San Francisco, CA without a degree?

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Line Cook
Average Salary: $43,222
In this role, you will prepare meals quickly and safely. You can work at well-known restaurants or food chains in the area. Attention to detail and teamwork are important.
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Housekeeping
Average Salary: $41,818
Housekeeping staff keep rooms clean and welcoming for guests. This job requires good organization and a friendly attitude. Many local hotels hire for this position.
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Server
Average Salary: $41,788
As a server, you will take orders and serve food to customers. Being friendly and efficient is key. You will work at popular eateries and cafes in the city.
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Barista
Average Salary: $40,792
Baristas craft coffee beverages for customers. They work in coffee shops and chains. They need to be quick and know how to use coffee machines well.
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Service Team Member
Average Salary: $38,693
This job includes greeting customers and helping them with their needs. They work at various businesses, including retail and service sectors. Good communication skills are important.
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Dishwasher
Average Salary: $38,480
Dishwashers clean dishes and kitchen tools. They work in busy restaurants and food outlets. Attention to detail and a strong work ethic are needed for this role.
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Which companies offer the top salaries in South San Francisco, CA?

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Calico Life Sciences
Average Salary: $196,220
Calico focuses on aging and related diseases. It offers competitive salaries and benefits.
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Denali Therapeutics
Average Salary: $192,084
Denali specializes in neuroscience drug development. It provides a rewarding work environment.
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CYTOKINETICS
Average Salary: $170,681
This company works on muscle activation and works in muscle-related disease treatment.
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Merck
Average Salary: $168,904
A global pharmaceutical company, Merck is known for its research and development.
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AbbVie
Average Salary: $154,076
AbbVie develops innovative treatments for immune and genetic disorders.
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TWIST BIOSCIENCE
Average Salary: $132,915
This biotech company specializes in DNA synthesis and gene editing.
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Thermo Fisher Scientific
Average Salary: $115,772
A global leader in scientific instruments and reagents, offering a variety of career opportunities.
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South San Francisco Unified School District
Average Salary: $100,611
The district provides educational services and employs teachers, administrators, and support staff.
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See's Candies
Average Salary: $95,203
This family-owned company is known for its delicious candies and sweets.
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Health Plan of San Mateo
Average Salary: $83,377
This healthcare provider offers various health plans and services to the community.
How does the cost of living in South San Francisco, CA compare to the national average?

The cost of living in South San Francisco, CA, stands significantly higher than the nationwide average. Specifically, the housing index in this area is recorded at 250. This means housing costs in South San Francisco are 150% higher than the national average. For those considering relocating or moving, this can significantly impact their budget.
Other areas of living expenses also show elevated costs. Groceries, for example, have an index of 120, indicating a 20% increase over the national average. Utilities follow closely with an index of 115, which is 15% above the nationwide average. Even transportation costs, indexed at 130, show a 30% rise. Healthcare, however, remains relatively close to the national average with an index of 110, only 10% higher. These statistics highlight the need for careful financial planning when considering a move to South San Francisco.



